A theory on prions
Jan. 9th, 2004 09:36 amI've been thinking about the subject a bit... and the following occurred to me:
Prions are an extinction mechanism. Assuming that cannibalism is not a normal behavior of a "healthy" species, the prion proteins that are generated in aged members of the species would never enter into younger members. But if cannibalism is the only way that the species can survive, a negative feedback loop is created that spirals the species into non-existence, essentially a check against species that can no longer flourish in the environment. The effects of prions become inherited, basically inserting a "time bomb" into the genetic legacy of the species.
In a normal evolutionary situation, we would never see the effects of prions because they would play out over many, many generations making the species "weaker" overall with a series of different malfunctions until it finally dies out. But since we are artificially accelerating the effects of prions by essentially forcing species into non-healthy behaviors (feeding domestic animals their peers), we get to see it happen much more quickly.
So why are prions so easily spread across species? Because what we are seeing is essentially a closed loop system - predators that depend on the non-healthy species to survive are also taken out of the system when they eat the non-healthy species. It's a very elegant mechanism for natural selection if you think about it this way.
Prions are an extinction mechanism. Assuming that cannibalism is not a normal behavior of a "healthy" species, the prion proteins that are generated in aged members of the species would never enter into younger members. But if cannibalism is the only way that the species can survive, a negative feedback loop is created that spirals the species into non-existence, essentially a check against species that can no longer flourish in the environment. The effects of prions become inherited, basically inserting a "time bomb" into the genetic legacy of the species.
In a normal evolutionary situation, we would never see the effects of prions because they would play out over many, many generations making the species "weaker" overall with a series of different malfunctions until it finally dies out. But since we are artificially accelerating the effects of prions by essentially forcing species into non-healthy behaviors (feeding domestic animals their peers), we get to see it happen much more quickly.
So why are prions so easily spread across species? Because what we are seeing is essentially a closed loop system - predators that depend on the non-healthy species to survive are also taken out of the system when they eat the non-healthy species. It's a very elegant mechanism for natural selection if you think about it this way.